Tuesday, July 5, 2011

Prenatal Antidepressants and Autism

When I'm working around the house, I'll often have crappy daytime tv on for background noise. The ads assume anyone home during the day is unemployed and/or disabled: train to be an ultrasound technician, get cash for your structured settlement, sign up for a Medicare Advantage plan, call a personal injury attorney.
I've falen...and I can't get up!

 Lately, they've started playing ads that speak to me: call a lawyer if you took antidepressants during pregnancy and your child suffered birth defects. These ads, and the spam that fills my inbox, say taking Zoloft has been linked to heart defects, persistent pulmonary hypertension of the newborn, neural tube defect, craniosynostosis, clubfoot, cleft palate, limb defects, and anal atresia.

Autism is not one of the conditions in the ads, but I have always wondered what effect my taking antidepressants during pregnancy had on Ryan's development.

When I was pregnant, my doctor told me the general medical consensus was that the benefit of treating the mother's depression outweighed any known risks of fetal exposure to SSRIs.

Over the last five years, several studies have pointed to a possible connection between the use of SSRIs in pregnancy and the development of autism. The most recent, and most damning, came this week in the Archives of General Psychology. That study suggested that use of SSRIs during pregnancy - especially during the first trimester - can double or even triple the chances a baby will be diagnosed with an autism spectrum disorder. And it further noted that "No increase in risk was found for mothers with a history of mental health treatment in the absence of prenatal exposure to selective serotonin reuptake inhibitors," meaning it's likely that the problem lies in the drugs, not in the underlying condition that may or may not lead to the use of drugs.

That said, the vast majority of children with autism were not exposed to SSRIs in utero, and the vast majority of children exposed to SSRIs in utero do not go on to develop autism. There's a complicated mix of genetic and environmental factors at play here, and I look forward to the follow-up studies.

I believe I made the right decision to continue to treat my depression during my pregnancy. According to the American Pregnancy Association,
Depression that is not treated can have potential dangerous risks to the mother and baby. Untreated depression can lead to poor nutrition, drinking, smoking, and suicidal behavior, which can then cause premature birth, low birth weight, and developmental problems. A woman who is depressed often does not have the strength or desire to adequately care for herself or her developing baby. Babies born to mothers who are depressed may also be less active, show less attention and are more irritable and agitated than babies born to moms who are not depressed. This is why getting the right help is so important for both mom and baby.
Great risks, indeed.

I must keep reminding myself of those risks so I don't fall into the tempting spiral of self-blame for my child's challenges.


  1. I took antidepressant during my first and second pregnancy. My second child, a 10 year old boy now has Asberger's, ADHD, OCD...... HE IS WONDERFUL....I was and am a diabetic. I also knew there was something different about him before he had the MMR shot. I believe Jacob is who he is: One of God's special children just like all of us. I believe we are all unique in our own way. Its too much trouble to worry about how he got that way all we can do now is make sure how they turn out.

  2. I took zoloft during my first pregnancy & my son is Autistic. I would not take it during my second & my daughter is okay. Who knows.... either way none if it is our fault. I believe both my husband & myself are autistic. I noticed a difference from the first few weeks. Certainly was there before immunisation. We just keep riding the roller coaster of this ASD journey. ryansmum2008@hotmail.com


Keep it civil, people.